Development of an oncogenic dedifferentiation SOX signature with prognostic significance in hepatocellular carcinoma.
Gradual loss of terminal differentiation markers and benefits of stem cell-like properties is the main hall mark of the development of malignant cancer. Pluripotent stem cells SOX family transcription factors play important role in regulating tumor plasticity and specifications descent.
The purpose of this study to establish the new SOX signature to monitor the extent of the dedifferentiation of the tumor and predict the prognostic significance in hepatocellular carcinoma (HCC) .the RNA-seq data from The Cancer Genome Atlas (TCGA) project LIHC chronologically divided into training (n = 188) and testing cohort (n = 189).
Liri-JP project of the International Cancer Genome Consortium (ICGC) data portal is used as an independent validation cohort (n = 232). Kaplan-Meier and Cox multivariable analysis was used to test the clinical significance and prognostic value of the signature genes.The SOX gene family members found aberrantly expressed in HCC patients clinically. A five SOX gene signature with established prognostic value in the training group. The SOX gene signatures are found closely associated with tumor grade and stage of the tumor.
markers dedifferentiation of liver cancer (AFP, CD133, EpCAM, and KRT19) found increased while a marker of hepatocyte terminal differentiation (ALB, G6PC, CYP3A4, and HNF4A) decreasing from HCC patients with a score of signatures SOX lower for patients with a high score SOX signature. Kaplan-Meier survival analysis further shows that the newly founded signature SOX excited to predict the overall survival of patients in both the training, testing and independent validation of oncogenic dedifferentiation cohort.An SOX signature gift great potential in predicting the prognostic significance in HCC, and may provide a novel biomarker for further precision in clinical oncology.
Development of an oncogenic dedifferentiation SOX signature with prognostic significance in hepatocellular carcinoma.
Update on legacy and Gastrointestinal polyposis colon cancer.
It is estimated that 5-10% of colorectal cancers arise due to known genetic syndromes. Individuals with this cancer syndrome ekstrakolon cancer risk. Polyposis and hereditary nonpolyposis syndrome is generally recognized. The entry of next generation sequencing technology, particularly multiple-gene panel test, in routine laboratory practice have been made to identify the cause of the disease is significantly easier.To summarizes current knowledge of the causes, clinical manifestations, diagnostic criteria, and recommendations for the presymptomatic screening of individuals at risk of gastrointestinal polyposis and hereditary colorectal cancer syndromes. We dicuss currently defined syndrome is detected by multiple-gene panel generation sequencing;
These include constitutional deficiencies repair mismatches (mutations of genes MLH1, MSH2, MSH6, PMS2 biallelic), gastric adenocarcinoma and polyps proximal stomach (APC gene), polyposis NTHL1 related, polymerase proofreading associated polyps (POLD1, gene POLE), juvenile polyposis (SMAD4 , gene BMPR1A), and serrated polyposis syndrome.
Another aim is to summarize the latest knowledge about well-known syndromes, including heredity nonpolyposis bowel cancer (Lynch syndrome), familial adenomatous polyposis, MUTYH associated polyposis, and Peutz-Jeghers and Cowden / PTEN hamartoma tumor syndromes.Awareness of descent polyposis / bowel cancer syndromes allow early diagnosis and prevention of cancer in affected individuals and their families.
Description: A polyclonal antibody for detection of JIP-2 from Human, Mouse, Rat. This JIP-2 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human JIP-2 at AA rangle: 550-630
Description: A polyclonal antibody for detection of JIP-2 from Human, Mouse, Rat. This JIP-2 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human JIP-2 at AA rangle: 550-630
Description: A polyclonal antibody for detection of JIP-1 from Human, Mouse, Rat. This JIP-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human JIP-1 around the non-phosphorylation site of T103
Description: A polyclonal antibody for detection of JIP-1 from Human, Mouse, Rat. This JIP-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human JIP-1 around the non-phosphorylation site of T103
Description: A polyclonal antibody for detection of JIP-1 from Human, Mouse, Rat. This JIP-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human JIP-1 around the non-phosphorylation site of T103
Description: A polyclonal antibody for detection of JIP-1 phospho Thr103) from Human, Mouse, Rat. This JIP-1 phospho Thr103) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human JIP-1 around the phosphorylation site of T103
Description: A polyclonal antibody for detection of JIP-1 phospho Thr103) from Human, Mouse, Rat. This JIP-1 phospho Thr103) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human JIP-1 around the phosphorylation site of T103
Description: A polyclonal antibody for detection of JIP-1 phospho Thr103) from Human, Mouse, Rat. This JIP-1 phospho Thr103) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human JIP-1 around the phosphorylation site of T103
Description: A Rabbit Polyclonal antibody against JIP-1 (phospho Thr103) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A Rabbit Polyclonal antibody against JIP-1 (phospho Thr103) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A polyclonal antibody for detection of JIP4 from Human, Mouse. This JIP4 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human JIP4 protein at amino acid sequence of 590-670
Description: A polyclonal antibody for detection of JIP4 from Human, Mouse. This JIP4 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human JIP4 protein at amino acid sequence of 590-670
Description: A polyclonal antibody for detection of JIP4 from Human, Mouse. This JIP4 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human JIP4 protein at amino acid sequence of 590-670
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JIP3 . This antibody is tested and proven to work in the following applications:
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human JIP3 / Syd2 / JSAP1 (N-Term). This antibody is tested and proven to work in the following applications:
Description: A polyclonal antibody for detection of 14-3-3 ? from Human, Mouse, Rat. This 14-3-3 ? antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human 14-3-3 ? at AA range: 180-260
Description: A polyclonal antibody for detection of 14-3-3 ? from Human, Mouse, Rat. This 14-3-3 ? antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human 14-3-3 ? at AA range: 180-260
Description: A polyclonal antibody for detection of 14-3-3 ? from Human, Mouse, Rat. This 14-3-3 ? antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human 14-3-3 ? at AA range: 180-260
Description: A polyclonal antibody for detection of 14-3-3 ? from Human, Mouse. This 14-3-3 ? antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human 14-3-3 ? at AA rangle: 10-90
Description: A polyclonal antibody for detection of 14-3-3 ? from Human, Mouse. This 14-3-3 ? antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human 14-3-3 ? at AA rangle: 10-90
Description: A polyclonal antibody for detection of 14-3-3 ? from Human, Mouse. This 14-3-3 ? antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human 14-3-3 ? at AA rangle: 10-90
Description: A polyclonal antibody for detection of 14-3-3 ? from Human, Mouse, Rat. This 14-3-3 ? antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human 14-3-3 ? at AA range: 30-110
Description: A polyclonal antibody for detection of 14-3-3 ? from Human, Mouse, Rat. This 14-3-3 ? antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human 14-3-3 ? at AA range: 30-110
Description: A polyclonal antibody for detection of 14-3-3 ? from Human, Mouse, Rat. This 14-3-3 ? antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human 14-3-3 ? at AA range: 30-110
Description: A polyclonal antibody for detection of 14-3-3 ? from Mouse, Rat. This 14-3-3 ? antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein
Description: A polyclonal antibody for detection of 14-3-3 ? from Mouse, Rat. This 14-3-3 ? antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein
Description: A polyclonal antibody for detection of 14-3-3 ? from Mouse, Rat. This 14-3-3 ? antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein
Description: A Rabbit Polyclonal antibody against 14-3-3 ? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A Rabbit Polyclonal antibody against 14-3-3 ? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A Rabbit Polyclonal antibody against 14-3-3 ? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A Rabbit Polyclonal antibody against 14-3-3 ? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A Rabbit Polyclonal antibody against 14-3-3 ? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IP, IF, WB, ELISA
Description: A Rabbit Polyclonal antibody against 14-3-3 ? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IP, IF, WB, ELISA
Description: A Rabbit Polyclonal antibody against 14-3-3 ? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A Rabbit Polyclonal antibody against 14-3-3 ? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A Rabbit Polyclonal antibody against 14-3-3 ?/? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A Rabbit Polyclonal antibody against 14-3-3 ?/? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A Rabbit Polyclonal antibody against 14-3-3 ? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A Rabbit Polyclonal antibody against 14-3-3 ? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A Rabbit Polyclonal antibody against 14-3-3 ? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A Rabbit Polyclonal antibody against 14-3-3 ? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A Rabbit Polyclonal antibody against 14-3-3 ?/? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A Rabbit Polyclonal antibody against 14-3-3 ?/? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A polyclonal antibody for detection of GRK 3 from Human, Mouse, Rat. This GRK 3 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human GRK 3 at AA range: 330-410
Description: A polyclonal antibody for detection of GRK 3 from Human, Mouse, Rat. This GRK 3 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human GRK 3 at AA range: 330-410
Description: A polyclonal antibody for detection of GRK 3 from Human, Mouse, Rat. This GRK 3 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human GRK 3 at AA range: 330-410
Description: A polyclonal antibody for detection of ERK 3 from Human, Mouse, Rat. This ERK 3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human ERK 3 around the non-phosphorylation site of S189
Description: A polyclonal antibody for detection of ERK 3 from Human, Mouse, Rat. This ERK 3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human ERK 3 around the non-phosphorylation site of S189
Description: A polyclonal antibody for detection of ERK 3 from Human, Mouse, Rat. This ERK 3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human ERK 3 around the non-phosphorylation site of S189
Description: A polyclonal antibody for detection of GK1/3 from Human. This GK1/3 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human GK1/3 at AA range: 40-120
Description: A polyclonal antibody for detection of GK1/3 from Human. This GK1/3 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human GK1/3 at AA range: 40-120
Description: A polyclonal antibody for detection of GK1/3 from Human. This GK1/3 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human GK1/3 at AA range: 40-120
Description: A polyclonal antibody for detection of NT-3 from Human, Mouse, Rat. This NT-3 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human NT-3 protein at amino acid sequence of 180-230
Description: A polyclonal antibody for detection of NT-3 from Human, Mouse, Rat. This NT-3 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human NT-3 protein at amino acid sequence of 180-230
Description: A polyclonal antibody for detection of NT-3 from Human, Mouse, Rat. This NT-3 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human NT-3 protein at amino acid sequence of 180-230
Description: A polyclonal antibody for detection of ERK 3 from Human, Mouse, Rat. This ERK 3 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ERK 3 at AA range: 430-510
Description: A polyclonal antibody for detection of ERK 3 from Human, Mouse, Rat. This ERK 3 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ERK 3 at AA range: 430-510
Description: A polyclonal antibody for detection of ERK 3 from Human, Mouse, Rat. This ERK 3 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ERK 3 at AA range: 430-510
Description: A polyclonal antibody for detection of ERK 3 from Human, Mouse, Rat. This ERK 3 antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein
Description: A polyclonal antibody for detection of ERK 3 from Human, Mouse, Rat. This ERK 3 antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein
Description: A polyclonal antibody for detection of ERK 3 from Human, Mouse, Rat. This ERK 3 antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein
Description: A Rabbit Polyclonal antibody against TGF?3 from Human/Mouse/Rat/Monkey. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA
Description: A Rabbit Polyclonal antibody against TGF?3 from Human/Mouse/Rat/Monkey. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human 14-3-3 ε . This antibody is tested and proven to work in the following applications:
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human 14-3-3 θ . This antibody is tested and proven to work in the following applications:
Description: A polyclonal antibody for detection of Dlx-3 from Human, Mouse. This Dlx-3 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Dlx-3 at AA range: 40-120
Description: A polyclonal antibody for detection of Dlx-3 from Human, Mouse. This Dlx-3 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Dlx-3 at AA range: 40-120
Description: A polyclonal antibody for detection of IRF-3 from Human, Mouse, Rat. This IRF-3 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRF-3 around the non-phosphorylation site of S396
Description: A polyclonal antibody for detection of IRF-3 from Human, Mouse, Rat. This IRF-3 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRF-3 around the non-phosphorylation site of S396
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genetic counseling, presymptomatic testing of at-risk individuals, and efficient screening may be helpful to affected families. Thanks to Lenka Foretová, M.D., Ph.D., (Masaryk Memorial Cancer Institute, Brno) for a critical review of the manuscript and valuable advice. The author states he has no potential conflict of interest concerning medicines, products, or services used in this study. Editorial Board that the text met ICMJE recommendation for biomedical papers.
