JIP family of MAPK scaffold proteins

JIP family of MAPK scaffold proteins

JIP family of MAPK scaffold proteins | The components of MAPK
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Development of an oncogenic dedifferentiation SOX signature with prognostic significance in hepatocellular carcinoma.

Gradual loss of terminal differentiation markers and benefits of stem cell-like properties is the main hall mark of the development of malignant cancer. Pluripotent stem cells SOX family transcription factors play important role in regulating tumor plasticity and specifications descent.

The purpose of this study to establish the new SOX signature to monitor the extent of the dedifferentiation of the tumor and predict the prognostic significance in hepatocellular carcinoma (HCC) .the RNA-seq data from The Cancer Genome Atlas (TCGA) project LIHC chronologically divided into training (n = 188) and testing cohort (n = 189).

Liri-JP project of the International Cancer Genome Consortium (ICGC) data portal is used as an independent validation cohort (n = 232). Kaplan-Meier and Cox multivariable analysis was used to test the clinical significance and prognostic value of the signature genes.The SOX gene family members found aberrantly expressed in HCC patients clinically. A five SOX gene signature with established prognostic value in the training group. The SOX gene signatures are found closely associated with tumor grade and stage of the tumor.

markers dedifferentiation of liver cancer (AFP, CD133, EpCAM, and KRT19) found increased while a marker of hepatocyte terminal differentiation (ALB, G6PC, CYP3A4, and HNF4A) decreasing from HCC patients with a score of signatures SOX lower for patients with a high score SOX signature. Kaplan-Meier survival analysis further shows that the newly founded signature SOX excited to predict the overall survival of patients in both the training, testing and independent validation of oncogenic dedifferentiation cohort.An SOX signature gift great potential in predicting the prognostic significance in HCC, and may provide a novel biomarker for further precision in clinical oncology.

Development of an oncogenic dedifferentiation SOX signature with prognostic significance in hepatocellular carcinoma.
Development of an oncogenic dedifferentiation SOX signature with prognostic significance in hepatocellular carcinoma.

Update on legacy and Gastrointestinal polyposis colon cancer.

It is estimated that 5-10% of colorectal cancers arise due to known genetic syndromes. Individuals with this cancer syndrome ekstrakolon cancer risk. Polyposis and hereditary nonpolyposis syndrome is generally recognized. The entry of next generation sequencing technology, particularly multiple-gene panel test, in routine laboratory practice have been made to identify the cause of the disease is significantly easier.To summarizes current knowledge of the causes, clinical manifestations, diagnostic criteria, and recommendations for the presymptomatic screening of individuals at risk of gastrointestinal polyposis and hereditary colorectal cancer syndromes. We dicuss currently defined syndrome is detected by multiple-gene panel generation sequencing;

These include constitutional deficiencies repair mismatches (mutations of genes MLH1, MSH2, MSH6, PMS2 biallelic), gastric adenocarcinoma and polyps proximal stomach (APC gene), polyposis NTHL1 related, polymerase proofreading associated polyps (POLD1, gene POLE), juvenile polyposis (SMAD4 , gene BMPR1A), and serrated polyposis syndrome.

Another aim is to summarize the latest knowledge about well-known syndromes, including heredity nonpolyposis bowel cancer (Lynch syndrome), familial adenomatous polyposis, MUTYH associated polyposis, and Peutz-Jeghers and Cowden / PTEN hamartoma tumor syndromes.Awareness of descent polyposis / bowel cancer syndromes allow early diagnosis and prevention of cancer in affected individuals and their families.

JIP-3 Polyclonal Antibody

BT-AP04701-100ul 100ul Ask for price
Description: C-Jun-amino-terminal kinase-interacting protein 3 encoded by MAPK8IP3 shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

JIP-3 Polyclonal Antibody

BT-AP04701-20ul 20ul Ask for price
Description: C-Jun-amino-terminal kinase-interacting protein 3 encoded by MAPK8IP3 shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

JIP-3 Polyclonal Antibody

BT-AP04701-50ul 50ul Ask for price
Description: C-Jun-amino-terminal kinase-interacting protein 3 encoded by MAPK8IP3 shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

JIP-3 Polyclonal Antibody

E44H05099 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

JIP-3 Polyclonal Antibody

MBS9244097-01mL 0.1mL
EUR 415

JIP-3 Polyclonal Antibody

MBS9244097-5x01mL 5x0.1mL
EUR 1841

JIP-3 Polyclonal Antibody

MBS9408991-005mL 0.05mL
EUR 245

JIP-3 Polyclonal Antibody

MBS9408991-01mL 0.1mL
EUR 305

JIP-3 Polyclonal Antibody

MBS9408991-5x01mL 5x0.1mL
EUR 1230

JIP-3 Polyclonal Antibody

MBS8523417-01mg 0.1mg
EUR 305

JIP-3 Polyclonal Antibody

MBS8523417-01mLAF405L 0.1mL(AF405L)
EUR 465

JIP-3 Polyclonal Antibody

MBS8523417-01mLAF405S 0.1mL(AF405S)
EUR 465

JIP-3 Polyclonal Antibody

MBS8523417-01mLAF610 0.1mL(AF610)
EUR 465

JIP-3 Polyclonal Antibody

MBS8523417-01mLAF635 0.1mL(AF635)
EUR 465

JIP-3 Polyclonal Antibody

MBS2538527-002mL 0.02mL
EUR 140

JIP-3 Polyclonal Antibody

MBS2538527-006mL 0.06mL
EUR 180

JIP-3 Polyclonal Antibody

MBS2538527-012mL 0.12mL
EUR 260

JIP-3 Polyclonal Antibody

MBS2538527-02mL 0.2mL
EUR 405

JIP-3 Rabbit Polyclonal Antibody

ES2660-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against JIP-3 from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

JIP-3 Rabbit Polyclonal Antibody

ES2660-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against JIP-3 from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

JIP-3 Polyclonal Conjugated Antibody

C41084 100ul
EUR 476.4

JIP-3 Polyclonal Conjugated Antibody

MBS9449885-01mLAF350 0.1mL(AF350)
EUR 480

JIP-3 Polyclonal Conjugated Antibody

MBS9449885-01mLAF405 0.1mL(AF405)
EUR 480

JIP-3 Polyclonal Conjugated Antibody

MBS9449885-01mLAF488 0.1mL(AF488)
EUR 480

JIP-3 Polyclonal Conjugated Antibody

MBS9449885-01mLAF555 0.1mL(AF555)
EUR 480

JIP-3 Polyclonal Conjugated Antibody

MBS9449885-01mLBiotin 0.1mL(Biotin)
EUR 480

JIP-1 Polyclonal Antibody

ABP51660-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of JIP-1 from Human, Mouse, Rat. This JIP-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human JIP-1 around the non-phosphorylation site of T103

JIP-1 Polyclonal Antibody

ABP51660-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of JIP-1 from Human, Mouse, Rat. This JIP-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human JIP-1 around the non-phosphorylation site of T103

JIP-1 Polyclonal Antibody

ABP51660-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of JIP-1 from Human, Mouse, Rat. This JIP-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human JIP-1 around the non-phosphorylation site of T103

JIP-2 Polyclonal Antibody

ABP54357-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of JIP-2 from Human, Mouse, Rat. This JIP-2 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human JIP-2 at AA rangle: 550-630

JIP-2 Polyclonal Antibody

ABP54357-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of JIP-2 from Human, Mouse, Rat. This JIP-2 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human JIP-2 at AA rangle: 550-630

JIP-2 Polyclonal Antibody

ABP54357-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of JIP-2 from Human, Mouse, Rat. This JIP-2 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human JIP-2 at AA rangle: 550-630

JIP-1 Polyclonal Antibody

E20-72434 100ug
EUR 225
Description: Available in various conjugation types.

JIP-2 Polyclonal Antibody

E20-72435 100ug
EUR 225
Description: Available in various conjugation types.

JIP-2 Polyclonal Antibody

BT-AP04700-100ul 100ul Ask for price
Description: The mitogen-activated protein kinase 8 interacting protein 2 encoded by MAPK8IP2 is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells.

JIP-2 Polyclonal Antibody

BT-AP04700-20ul 20ul Ask for price
Description: The mitogen-activated protein kinase 8 interacting protein 2 encoded by MAPK8IP2 is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells.

JIP-2 Polyclonal Antibody

BT-AP04700-50ul 50ul Ask for price
Description: The mitogen-activated protein kinase 8 interacting protein 2 encoded by MAPK8IP2 is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells.

JIP-1 Polyclonal Antibody

BT-AP04699-100ul 100ul Ask for price
Description: MAPK8IP1 encodes a regulator of the pancreatic beta-cell function. C-Jun-amino-terminal kinase-interacting protein 1 is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). C-Jun-amino-terminal kinase-interacting protein 1 has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.

JIP-1 Polyclonal Antibody

BT-AP04699-20ul 20ul Ask for price
Description: MAPK8IP1 encodes a regulator of the pancreatic beta-cell function. C-Jun-amino-terminal kinase-interacting protein 1 is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). C-Jun-amino-terminal kinase-interacting protein 1 has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.

JIP-1 Polyclonal Antibody

BT-AP04699-50ul 50ul Ask for price
Description: MAPK8IP1 encodes a regulator of the pancreatic beta-cell function. C-Jun-amino-terminal kinase-interacting protein 1 is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). C-Jun-amino-terminal kinase-interacting protein 1 has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.

JIP-2 Polyclonal Antibody

E44H05098 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

JIP-1 Polyclonal Antibody

E44H02711 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

JIP-1 Polyclonal Antibody

MBS9244096-01mL 0.1mL
EUR 415

JIP-1 Polyclonal Antibody

MBS9244096-5x01mL 5x0.1mL
EUR 1841

JIP-1 Polyclonal Antibody

MBS8523415-01mg 0.1mg
EUR 305

JIP-1 Polyclonal Antibody

MBS8523415-01mLAF405L 0.1mL(AF405L)
EUR 465

JIP-1 Polyclonal Antibody

MBS8523415-01mLAF405S 0.1mL(AF405S)
EUR 465

JIP-1 Polyclonal Antibody

MBS8523415-01mLAF610 0.1mL(AF610)
EUR 465

JIP-1 Polyclonal Antibody

MBS8523415-01mLAF635 0.1mL(AF635)
EUR 465

JIP-2 Polyclonal Antibody

MBS8523416-01mg 0.1mg
EUR 305

JIP-2 Polyclonal Antibody

MBS8523416-01mLAF405L 0.1mL(AF405L)
EUR 465

JIP-2 Polyclonal Antibody

MBS8523416-01mLAF405S 0.1mL(AF405S)
EUR 465

JIP-2 Polyclonal Antibody

MBS8523416-01mLAF610 0.1mL(AF610)
EUR 465

JIP-2 Polyclonal Antibody

MBS8523416-01mLAF635 0.1mL(AF635)
EUR 465

JIP-1 Polyclonal Antibody

MBS2539277-002mL 0.02mL
EUR 140

JIP-1 Polyclonal Antibody

MBS2539277-006mL 0.06mL
EUR 180

JIP-1 Polyclonal Antibody

MBS2539277-012mL 0.12mL
EUR 260

JIP-1 Polyclonal Antibody

MBS2539277-02mL 0.2mL
EUR 405

JIP-1 Rabbit Polyclonal Antibody

ES2659-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against JIP-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

JIP-1 Rabbit Polyclonal Antibody

ES2659-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against JIP-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

JIP-2 Rabbit Polyclonal Antibody

ES5356-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against JIP-2 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

JIP-2 Rabbit Polyclonal Antibody

ES5356-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against JIP-2 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

JIP-1 (phospho Thr103) Polyclonal Antibody

ABP57049-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of JIP-1 phospho Thr103) from Human, Mouse, Rat. This JIP-1 phospho Thr103) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human JIP-1 around the phosphorylation site of T103

JIP-1 (phospho Thr103) Polyclonal Antibody

ABP57049-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of JIP-1 phospho Thr103) from Human, Mouse, Rat. This JIP-1 phospho Thr103) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human JIP-1 around the phosphorylation site of T103

JIP-1 (phospho Thr103) Polyclonal Antibody

ABP57049-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of JIP-1 phospho Thr103) from Human, Mouse, Rat. This JIP-1 phospho Thr103) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human JIP-1 around the phosphorylation site of T103

JIP-1 (phospho Thr103) Polyclonal Antibody

E20-60555 100ug
EUR 225
Description: Available in various conjugation types.

JIP-1(Phospho Thr103) Polyclonal Antibody

BT-AP10573-100ul 100ul Ask for price
Description: This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.

JIP-1(Phospho Thr103) Polyclonal Antibody

BT-AP10573-20ul 20ul Ask for price
Description: This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.

JIP-1(Phospho Thr103) Polyclonal Antibody

BT-AP10573-50ul 50ul Ask for price
Description: This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.

JIP-1 (phospho Thr103) Polyclonal Antibody

E44H01085 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

JIP-1 (phospho Thr103) Polyclonal Antibody

MBS9242240-01mL 0.1mL
EUR 425

JIP-1 (phospho Thr103) Polyclonal Antibody

MBS9242240-5x01mL 5x0.1mL
EUR 1887

JIP-1 (phospho Thr103) Polyclonal Antibody

MBS8520329-01mg 0.1mg
EUR 305

JIP-1 (phospho Thr103) Polyclonal Antibody

MBS8520329-01mLAF405L 0.1mL(AF405L)
EUR 465

JIP-1 (phospho Thr103) Polyclonal Antibody

MBS8520329-01mLAF405S 0.1mL(AF405S)
EUR 465

JIP-1 (phospho Thr103) Polyclonal Antibody

MBS8520329-01mLAF610 0.1mL(AF610)
EUR 465

JIP-1 (phospho Thr103) Polyclonal Antibody

MBS8520329-01mLAF635 0.1mL(AF635)
EUR 465

JIP-1 (phospho Thr103) Rabbit Polyclonal Antibody

ES8048-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against JIP-1 (phospho Thr103) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

JIP-1 (phospho Thr103) Rabbit Polyclonal Antibody

ES8048-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against JIP-1 (phospho Thr103) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Rabbit polyclonal anti-JIP-1 antibody

TA318944 100 µg Ask for price

Phospho-JIP-1 (T103) Polyclonal Antibody

MBS2538220-002mL 0.02mL
EUR 140

Phospho-JIP-1 (T103) Polyclonal Antibody

MBS2538220-006mL 0.06mL
EUR 180

Phospho-JIP-1 (T103) Polyclonal Antibody

MBS2538220-012mL 0.12mL
EUR 260

Phospho-JIP-1 (T103) Polyclonal Antibody

MBS2538220-02mL 0.2mL
EUR 405

Phospho-JIP-1 (T103) Polyclonal Antibody

MBS2538220-5x02mL 5x0.2mL
EUR 1725

JIP-3 Antibody

C11903-100ul 100μl
EUR 217
Description: JIP-3 Rabbit Polyclonal Antibody

JIP-3 Antibody

C11903-50ul 50μl
EUR 143.5
Description: JIP-3 Rabbit Polyclonal Antibody

JIP4 Polyclonal Antibody

ABP58988-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of JIP4 from Human, Mouse. This JIP4 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human JIP4 protein at amino acid sequence of 590-670

JIP4 Polyclonal Antibody

ABP58988-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of JIP4 from Human, Mouse. This JIP4 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human JIP4 protein at amino acid sequence of 590-670

JIP4 Polyclonal Antibody

ABP58988-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of JIP4 from Human, Mouse. This JIP4 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human JIP4 protein at amino acid sequence of 590-670

JIP4 Polyclonal Antibody

E11-201592 100ug/100ul
EUR 225
Description: Available in various conjugation types.

JIP4 Polyclonal Antibody

BT-AP10577-100ul 100ul Ask for price
Description: This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants.

JIP4 Polyclonal Antibody

BT-AP10577-20ul 20ul Ask for price
Description: This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants.

JIP4 Polyclonal Antibody

BT-AP10577-50ul 50ul Ask for price
Description: This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants.

JIP4 Polyclonal Antibody

E44H09199 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

JIP2 Polyclonal Antibody

MBS9234804-01mL 0.1mL
EUR 415

JIP2 Polyclonal Antibody

MBS9234804-5x01mL 5x0.1mL
EUR 1841

JIP4 Polyclonal Antibody

MBS8530946-01mg 0.1mg
EUR 305

JIP4 Polyclonal Antibody

MBS8530946-01mLAF405L 0.1mL(AF405L)
EUR 465

JIP4 Polyclonal Antibody

MBS8530946-01mLAF405S 0.1mL(AF405S)
EUR 465

JIP4 Polyclonal Antibody

MBS8530946-01mLAF610 0.1mL(AF610)
EUR 465

JIP4 Polyclonal Antibody

MBS8530946-01mLAF635 0.1mL(AF635)
EUR 465

Polyclonal JIP3 Antibody

APR16952G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JIP3 . This antibody is tested and proven to work in the following applications:

JIP4 Rabbit Polyclonal Antibody

ES10538-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against JIP4 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

JIP4 Rabbit Polyclonal Antibody

ES10538-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against JIP4 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

JIP1 Rabbit Polyclonal Antibody

E10G33873 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

JIP-1 Antibody

3664-100 each
EUR 379.2

JIP-1 Antibody

3664-30T each
EUR 175.2

JIP-1 Antibody

B0954-100ul 100μl
EUR 217
Description: JIP-1 Rabbit Polyclonal Antibody

JIP-1 Antibody

B0954-50ul 50μl
EUR 143.5
Description: JIP-1 Rabbit Polyclonal Antibody

JIP-2 Antibody

C10973-100ul 100μl
EUR 217
Description: JIP-2 Rabbit Polyclonal Antibody

JIP-2 Antibody

C10973-50ul 50μl
EUR 143.5
Description: JIP-2 Rabbit Polyclonal Antibody

Rabbit polyclonal anti-MAPK8IP3 / JIP3 antibody

TA315223 100 µl Ask for price

Rabbit polyclonal JIP1 (Ab-103) antibody

TA314919 100 µl Ask for price

14-3-3 ? Polyclonal Antibody

ABP50542-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of 14-3-3 ? from Human, Mouse, Rat. This 14-3-3 ? antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human 14-3-3 ? at AA range: 180-260

14-3-3 ? Polyclonal Antibody

ABP50542-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of 14-3-3 ? from Human, Mouse, Rat. This 14-3-3 ? antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human 14-3-3 ? at AA range: 180-260

14-3-3 ? Polyclonal Antibody

ABP50542-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of 14-3-3 ? from Human, Mouse, Rat. This 14-3-3 ? antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human 14-3-3 ? at AA range: 180-260

14-3-3 ? Polyclonal Antibody

ABP57184-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of 14-3-3 ? from Mouse, Rat. This 14-3-3 ? antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein

14-3-3 ? Polyclonal Antibody

ABP57184-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of 14-3-3 ? from Mouse, Rat. This 14-3-3 ? antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein

14-3-3 ? Polyclonal Antibody

ABP57184-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of 14-3-3 ? from Mouse, Rat. This 14-3-3 ? antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein

14-3-3 ? Polyclonal Antibody

ABP54573-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of 14-3-3 ? from Human, Mouse. This 14-3-3 ? antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human 14-3-3 ? at AA rangle: 10-90

14-3-3 ? Polyclonal Antibody

ABP54573-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of 14-3-3 ? from Human, Mouse. This 14-3-3 ? antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human 14-3-3 ? at AA rangle: 10-90

14-3-3 ? Polyclonal Antibody

ABP54573-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of 14-3-3 ? from Human, Mouse. This 14-3-3 ? antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human 14-3-3 ? at AA rangle: 10-90

14-3-3 ? Polyclonal Antibody

ABP56524-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of 14-3-3 ? from Human, Mouse, Rat. This 14-3-3 ? antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human 14-3-3 ? at AA range: 30-110

14-3-3 ? Polyclonal Antibody

ABP56524-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of 14-3-3 ? from Human, Mouse, Rat. This 14-3-3 ? antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human 14-3-3 ? at AA range: 30-110

14-3-3 ? Polyclonal Antibody

ABP56524-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of 14-3-3 ? from Human, Mouse, Rat. This 14-3-3 ? antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human 14-3-3 ? at AA range: 30-110

14-3-3 Polyclonal Antibody

MBS668093-0025mg 0.025mg
EUR 175

14-3-3 Polyclonal Antibody

MBS668093-01mg 0.1mg
EUR 325

14-3-3 Polyclonal Antibody

MBS668093-5x01mg 5x0.1mg
EUR 1465

14-3-3 polyclonal antibody

MBS566556-0025mL 0.025mL
EUR 240

14-3-3 polyclonal antibody

MBS566556-01mL 0.1mL
EUR 520

14-3-3 polyclonal antibody

MBS566556-5x01mL 5x0.1mL
EUR 2290

JIP 1 antibody

20R-1697 100 ug
EUR 807.6
Description: Rabbit polyclonal JIP 1 antibody

Polyclonal JIP3 / Syd2 / JSAP1 Antibody (N-Term)

APR16951G 0.1 mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human JIP3 / Syd2 / JSAP1 (N-Term). This antibody is tested and proven to work in the following applications:

Polyclonal Antibody to 14-3-3

MBS669577-0025mg 0.025mg
EUR 175

Polyclonal Antibody to 14-3-3

MBS669577-01mg 0.1mg
EUR 325

Polyclonal Antibody to 14-3-3

MBS669577-5x01mg 5x0.1mg
EUR 1465

JIP3 (MAPK8IP3) rabbit polyclonal antibody, Aff - Purified

AP01286PU-N 100 µg Ask for price

JIP2 (MAPK8IP2) rabbit polyclonal antibody, Aff - Purified

AP06724PU-N 100 µg Ask for price

Polyclonal 14-3-3 ε Antibody

APR11359G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human 14-3-3 ε . This antibody is tested and proven to work in the following applications:

Polyclonal 14-3-3 θ Antibody

APR11360G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human 14-3-3 θ . This antibody is tested and proven to work in the following applications:

14-3-3 ε Polyclonal Antibody

40523 100ul
EUR 319

14-3-3 ε Polyclonal Antibody

40523-100ul 100ul
EUR 302.4

14-3-3 ε Polyclonal Antibody

40523-50ul 50ul
EUR 224.4

14-3-3 ζ Polyclonal Antibody

40524 100ul
EUR 319

14-3-3 ζ Polyclonal Antibody

40524-100ul 100ul
EUR 302.4

14-3-3 ζ Polyclonal Antibody

40524-50ul 50ul
EUR 224.4

14-3-3 ζ Polyclonal Antibody

40525-100ul 100ul
EUR 302.4

14-3-3 ζ Polyclonal Antibody

40525-50ul 50ul
EUR 224.4

14-3-3 ε Polyclonal Antibody

E040523 100μg/100μl
EUR 255
Description: Available in various conjugation types.

14-3-3 ζ Polyclonal Antibody

E040524 100μg/100μl
EUR 255
Description: Available in various conjugation types.

14-3-3 ζ Polyclonal Antibody

E040525 100μg/100μl
EUR 255
Description: Available in various conjugation types.

14-3-3 ε Polyclonal Antibody

E20-53355 100ug
EUR 225
Description: Available in various conjugation types.

genetic counseling, presymptomatic testing of at-risk individuals, and efficient screening may be helpful to affected families. Thanks to Lenka Foretová, M.D., Ph.D., (Masaryk Memorial Cancer Institute, Brno) for a critical review of the manuscript and valuable advice. The author states he has no potential conflict of interest concerning medicines, products, or services used in this study. Editorial Board that the text met ICMJE recommendation for biomedical papers.