juvenile polyps are the most common types of polyps in children but rare in adults. inflammatory bowel disease (IBD) patients had the same spectrum of symptoms as patients with juvenile polyps. Both patients with polyps teenagers and people with active IBD have high fecal calprotectin levels. Four cases of children with ulcerative colitis (UC) with solitary juvenile polyps and one adult case with UC with juvenile polyposis syndrome have been reported in the diagnosis of UC, while there was no case of adults with UC with solitary juvenile polyps were reported in men literature.

A 37 years with a 12 year history of UC was brought to our clinic because of the increased frequency of bowel movements. UC was diagnosed at the age of 25. As the lesions confined to the rectum, sulfasalazine Mesalazine suppositories or suppositories are used. Patients were followed at an outpatient clinic, and a colonoscopy done every one or two years. The latest inspection conducted three years before in the presence of proctitis.

More recently, the patient complained of three to five bowel movements a day. There is mucus in the stool but no blood visible. Colonoscopy revealed a solitary polyp, about 1.5 cm, with a short and wide rods in the transverse colon mucosa surrounded by congestive and edema. The patient had no family history of colorectal polyps or cancer. polyp was successfully removed by endoscopic mucosal resection.

Histopathological examination revealed that the juvenile polyp is a polyp without signs of malignant. Immunohistochemical staining for p53 expression of wild type and p53 excess undetected. Ki-67 labeling index was 3% .This is the first case of adult UC patients with solitary juvenile polyps in the 12-year follow-up. The correlation between juvenile polyps and IBD activity requires further research.

Diagnosis and management of a solitary colorectal juvenile polyp in an adult during follow-up for ulcerative colitis: A case report.
Diagnosis and management of a solitary colorectal juvenile polyp in an adult during follow-up for ulcerative colitis: A case report.

juvenile papillomatosis of breast (Swiss cheese disease) have frequent association with PIK3CA and / or mutation of AKT1.

Juvenile papillomatosis (JP), the so-called Swiss cheese disease is a rare benign breast disease of young adults. Associations (up 28%) with breast cancer in the family affected patients have been reported. A cystic mass breast lesions and calcifications multinodular JP characterize the imaging study.

Breast cancer develops only at very low part of the patient. JP molecular background has not been studied until now. In this study, we discuss the case of JP mutation analysis and correlate these results with follow-up and family-history in the context of the comprehensive review of the literature JP. We identified 13 cases that meet the criteria of JP. All patients were women with an average age of 38 years (26 to 50 years). follow-up information is available in 11 of 13 patients. Quite paraffin embedded tissue and DNA quality was good for the next generation sequencing (NGS) is available in 10 patients.

In 5 of the 10 patients, we found PIK3CA mutations in 2 of 10 patients in the AKT1 mutation hotspot known. further mutation in the MET gene, FGFR3, PTEN, ATM, NF1 and gnas detected in individual patients. Some of these mutations are present at high allele frequencies showed mutations in the germ line. 2 of 3 patients with a positive family history had PIK3CA mutations; one patient with a positive family history had a mutation in AKT1.

Hydrogen Peroxide Assay Kit

NAT1002 1KIT
EUR 308.4

ProtoBlock System

NAT1004 1KIT
EUR 122.4

450ML PBS 10X

NAT1006 450ML
EUR 96

4L PBS 10X

NAT1008 4L
EUR 238.8

ProtoGlow ECL 200ml Kit

NAT1010 EACH
EUR 354

ProtoGlow ECL 500ml Kit

NAT1012 EACH
EUR 627.6

100G Acrylamide

NAT1014 100G
EUR 120

500G Acrylamide

NAT1016 500G
EUR 261.6

1KG Acrylamide

NAT1018 1KG
EUR 412.8

25G AquaPor LE

NAT1020 25G
EUR 132

100G AquaPor LE GTAC

NAT1022 100G
EUR 250.8

500G AquaPor LE GTAC

NAT1024 500G
EUR 878.4

25G AquaPor ES

NAT1026 25G
EUR 152.4

100G AquaPor ES

NAT1028 100G
EUR 350.4

25G AquaPor LM

NAT1030 25G
EUR 288

100G AquaPor LM

NAT1032 100G
EUR 860.4

25G AquaPor HR

NAT1034 25G
EUR 236.4

100G AquaPor HR

NAT1036 100G
EUR 592.8

25G AquaPor 3:1

NAT1038 25G
EUR 250.8

100G AquaPor 3:1

NAT1040 100G
EUR 570

25G Bis (Methylene Bis-Acrylamide)

NAT1042 25G
EUR 100.8

25G DATD Ultrapure

NAT1044 25G
EUR 168

250G Glycine

NAT1046 250G
EUR 94.8

1KG Glycine Ultrapure

NAT1048 1KG
EUR 128.4

250G Tris

NAT1050 250G
EUR 102

1KG Tris Ultrapure

NAT1052 1KG
EUR 177.6

100G Tricine

NAT1054 100G
EUR 120

100G Ion Exchange Resin (mixed bed)

NAT1056 100G
EUR 96

25G Riboflavin

NAT1058 25G
EUR 96

25ML TEMED

NAT1060 25ML
EUR 99.6

25G Ammonium Persulfate

NAT1062 25G
EUR 96

100G Ammonium Persulfate

NAT1064 100G
EUR 118.8

1G Dithiothreitol (DTT)

NAT1066 1G
EUR 103.2

5G Dithiothreitol (DTT)

NAT1068 5G
EUR 183.6

50ML 2-Mercaptoethanol

NAT1070 50ML
EUR 112.8

100G SDS Ultrapure

NAT1072 100G
EUR 111.6

1KG SDS Ultrapure

NAT1074 1KG
EUR 457.2

250G Urea

NAT1076 250G
EUR 98.4

1KG Urea

NAT1078 1KG
EUR 138

450ML Glycerol Ultrapure

NAT1080 450ML
EUR 132

200ML Tween 20 Ultrapure

NAT1082 200ML
EUR 132

1L Tween 20

NAT1084 1L
EUR 169.2

200ML Formamide

NAT1086 200ML
EUR 111.6

500ML Boric Acid

NAT1088 500ML
EUR 103.2

100G EDTA

NAT1090 100G
EUR 94.8

500G EDTA

NAT1092 500G
EUR 177.6

GelDry Film 11 X 12 cm

NAT1094 PK50
EUR 100.8

25ML Formamide CE

NAT1096 25ML Ask for price

25ML Glass Bond

NAT1098 25ML
EUR 158.4

450ML Glass Free

NAT1100 450ML
EUR 196.8

GelDry Film 22.5 X 22.5 cm

NAT1102 PK50
EUR 130.8

1L DEPC Treated Water

NAT1104 1L
EUR 120

Sterling Rapid Silver Stain Kit

NAT1106 1KIT
EUR 265.2

1L ProtoBlue Safe

NAT1108 1L
EUR 159.6

4L ProtoBlue Safe

NAT1110 4L
EUR 282

1L ProtoStain Blue

NAT1112 1L
EUR 164.4

25ML Nuclistain

NAT1114 25ML
EUR 128.4

450ML AcrylaGel 30%

NAT1116 450ML
EUR 128.4

1L AcrylaGel 30%

NAT1118 1L
EUR 177.6

450ML Bis-AcrylaGel 2%

NAT1120 450ML
EUR 98.4

1L Bis-AcrylaGel 2%

NAT1122 1L
EUR 111.6

450ML UreaGel 29:1 Concentrate

NAT1124 450ML
EUR 133.2

1L UreaGel 29:1 Concentrate

NAT1126 1L
EUR 183.6

UreaGel 29:1 System 1L Kit

NAT1128 EACH
EUR 171.6

UreaGel 29:1 System 2.2L Kit

NAT1130 EACH
EUR 253.2

450ML SequaGel UreaGel Concentrate

NAT1132 450ML
EUR 126

1L SequaGel UreaGel Concentrate

NAT1134 1L
EUR 160.8

SequaGel Sequencing System 1L Kit

NAT1136 1KIT
EUR 171.6

SequaGel Sequencing System 2.2L Kit

NAT1138 EACH
EUR 253.2

100ML SequaGel Buffer

NAT1140 100ML
EUR 80.4

200ML SequaGel UreaGel Buffer

NAT1142 200ML
EUR 84

450ML SequaGel UreaGel-6

NAT1144 450ML
EUR 115.2

1L SequaGel UreaGel-6

NAT1146 1L
EUR 151.2

450ML SequaGel UreaGel-8

NAT1148 450ML
EUR 115.2

1L SequaGel UreaGel-8

NAT1150 1L
EUR 151.2

450ML SequaGel UreaGel Diluent

NAT1152 450ML
EUR 90

1L SequaGel UreaGel Diluent

NAT1154 1L
EUR 103.2

90ML SequaGel Complete Buffer

NAT1156 90ML
EUR 79.2

200ML SequaGel UreaGel Complete Buffer

NAT1158 200ML
EUR 85.2

450ML SequaGel XR

NAT1160 450ML
EUR 126

1L SequaGel XR

NAT1162 1L
EUR 165.6

100ML SequaGel XR Concentrate

NAT1164 100ML
EUR 128.4

450ML SequaGel XR Concentrate

NAT1166 450ML
EUR 361.2

200ML SequaGel MD Monomer Solution

NAT1168 200ML
EUR 220.8

SequaGel MD SSCP Kit

NAT1170 1KIT
EUR 253.2

SequaGel MD Heteroduplex Kit

NAT1172 EACH
EUR 265.2

1.2ML SequaGel MD SSCP Stop Solution

NAT1174 1.2ML
EUR 85.2

450ML AccuGel 19:1 (30%)

NAT1176 450ML
EUR 126

1L AccuGel 19:1 (30%)

NAT1178 1L
EUR 165.6

450ML AccuGel 19:1 (40%)

NAT1180 450ML
EUR 130.8

1L AccuGel 19:1 (40%)

NAT1182 1L
EUR 168

450ML AccuGel 29:1 (30%)

NAT1184 450ML
EUR 126

1L AccuGel 29:1 (30%)

NAT1186 1L
EUR 165.6

450ML AccuGel 29:1 (40%)

NAT1188 450ML
EUR 130.8

1L AccuGel 29:1 (40%)

NAT1190 1L
EUR 168

1.2ML Triple Dye Loading Buffer (6X)

NAT1192 1.2ML
EUR 85.2

UreaGel Loading Buffer

NAT1194 10X1ML
EUR 222

1L TBE 10X

NAT1196 1L
EUR 98.4

4L TBE 10X

NAT1198 4L
EUR 145.2

1L TBE 5X

NAT1200 1L
EUR 92.4

4L TBE 5X

NAT1202 4L
EUR 111.6

25ML TE BUFFER 100X

NAT1204 25ML
EUR 98.4

25ML 10X CE Buffer

NAT1206 25ML
EUR 138

100ML 10X CE Buffer

NAT1208 100ML
EUR 196.8

450ML 20X Tris-MOPS SDS

NAT1210 450ML
EUR 130.8

450ML 20X Tris-MEPS SDS

NAT1212 450ML
EUR 130.8

1L Tris-Tricine-SDS PAGE Buffer (10X)

NAT1214 1L
EUR 217.2

1L Tris-Glycine-SDS PAGE Buffer (10X)

NAT1216 1L
EUR 105.6

4L Tris-Glycine-SDS PAGE Buffer (10X)

NAT1218 4L
EUR 148.8

1L TTE Glycerol Tolerant Buffer 20X

NAT1220 1L
EUR 160.8

1L TAE Buffer 50X

NAT1222 1L
EUR 148.8

1L SSC Buffer 20X

NAT1224 1L
EUR 98.4

4L SSC Buffer 20X

NAT1226 4L
EUR 174

100ML SDS Solution 20%

NAT1228 100ML
EUR 92.4

450ML SDS Solution 20%

NAT1230 450ML
EUR 138

1L Denaturation Solution

NAT1232 1L
EUR 102

1L Neutralization Solution

NAT1234 1L
EUR 102

50G Dextran Sulfate

NAT1236 50G
EUR 193.2

250G Dextran Sulfate

NAT1238 250G
EUR 524.4

1L Tris-Glycine Electroblotting Buffer 10X

NAT1240 1L
EUR 102

4L Tris-Glycine Electroblotting Buffer 10X

NAT1242 4L
EUR 145.2

1L TBS (10X) Tris Buffered Saline

NAT1244 1L
EUR 126

1L TBST (10X) Tris Buffered Saline w/Tween 20

NAT1246 1L
EUR 126

ProtoGel Sample Prep Kit

NAT1248 EACH
EUR 223.2

Protein Loading Buffer Blue 2X

NAT1250 10X1ML
EUR 105.6

Protein Loading Buffer 5X

NAT1252 10X1ML
EUR 151.2

50ML Protein Precipitation Kit

NAT1254 50ML
EUR 270

100ML ProtoLift Western Strip Buffer

NAT1256 100ML
EUR 121.2

450ML ProtoGel (30%)

NAT1258 450ML
EUR 136.8

1L ProtoGel (30%)

NAT1260 1L
EUR 187.2

450ML ProtoGel (40%)

NAT1262 450ML
EUR 157.2

1L ProtoGel (40%)

NAT1264 1L
EUR 204

450ML ProtoGel Resolving Buffer 4X

NAT1266 450ML
EUR 100.8

1L ProtoGel Resolving Buffer

NAT1268 1L
EUR 128.4

200ML ProtoGel Stacking Buffer

NAT1270 200ML
EUR 92.4

100ML ProtoGel Quick-Cast 12%

NAT1272 100ML
EUR 105.6

450ML ProtoGel Quick-Cast 12%

NAT1274 450ML
EUR 223.2

0.5ML Insite Markers

NAT1276 0.5ML
EUR 238.8

0.5ML ProtoMarkers

NAT1278 0.5ML
EUR 236.4

ProtoMetrics

NAT1280 EACH
EUR 242.4

1L EDTA 0.5M Solution

NAT1282 1L
EUR 183.6

1L Sodium Chloride 0.009 Solution

NAT1284 1L
EUR 140.4

1L Sodium Chloride 1M Solution

NAT1286 1L
EUR 140.4

1L Potassium Chloride 1M Solution

NAT1288 1L
EUR 140.4

1L Tris-HCL 1M pH 7.2

NAT1290 1L
EUR 126

1L Tris-HCL 1M pH 7.4

NAT1292 1L
EUR 126

1L Tris-HCL 1M pH 7.6

NAT1294 1L
EUR 126

Histosol

NAT1296 EACH
EUR 106.8

Histosol

NAT1298 EACH
EUR 270

Mirskys Fixative (ready-to-use)

NAT1300 1USGALLON
EUR 96

Mirskys Fixative (ready-to-use)

NAT1302 EACH
EUR 228

200ML Mirskys Fixative

NAT1304 200ML
EUR 92.4

2L Mirskys Fixative

NAT1306 2L
EUR 134.4

100ML Histomount

NAT1308 100ML
EUR 86.4

450ML Histomount

NAT1310 450ML
EUR 111.6

Calci-Clear

NAT1312 EACH
EUR 93.6

Calci-Clear

NAT1314 EACH
EUR 153.6

Calci-Clear

NAT1316 EACH
EUR 463.2

Calci-Clear Rapid

NAT1318 EACH
EUR 90

Calci-Clear Rapid

NAT1320 EACH
EUR 153.6

Calci-Clear Rapid

NAT1322 EACH
EUR 463.2

100ML Hydromount

NAT1324 100ML
EUR 110.4

Neutralin

NAT1326 5USGALLON
EUR 136.8

100ML Omnimount

NAT1328 100ML
EUR 93.6

Histo-Clear

NAT1330 1 US gallon
EUR 184

Histo-Clear

NAT1332 5 US gallons
EUR 699.6

Histo-Clear II

NAT1334 1 US gallon
EUR 151.2

Histo-Clear II

NAT1336 5 US gallons
EUR 457.2

1L HarrisHematoxylin

NAT1338 1L
EUR 147.6

100ML Eosin Solution

NAT1340 100ML
EUR 106.8

1L Scotts Tapwater

NAT1342 1L
EUR 90

25G Alcian Blue

NAT1344 25G
EUR 194.4

25G Biebrich Scarlet

NAT1346 25G
EUR 144

25G Fast Green FCF

NAT1348 25G
EUR 192

25G Basic Fuchsin

NAT1350 25G
EUR 352.8

25G Methylene Blue

NAT1352 25G
EUR 187.2

25G Amido Black 10B

NAT1354 25G
EUR 176.4

5G Bromocresol Green

NAT1356 5G
EUR 187.2

10G Bromophenol Blue

NAT1358 10G
EUR 169.2

10G Coomassie Blue R-250

NAT1360 10G
EUR 123.6

10G Coomassie Blue G-250

NAT1362 10G
EUR 177.6

10G Methyl Green

NAT1364 10G
EUR 211.2

5G Pyronin Y

NAT1366 5G
EUR 261.6

25G Xylene Cyanol FF

NAT1368 25G
EUR 231.6

4L Hydrofluor

NAT1370 4L
EUR 200.4

4L Liquiscint

NAT1372 4L
EUR 168

4L Betafluor

NAT1374 4L
EUR 158.4

4L Monofluor

NAT1376 4L
EUR 234

4L Filtron-X

NAT1378 4L
EUR 252

Oxosol C14 Oxidizer

NAT1380 EACH
EUR 322.8

1L Oxosol 306

NAT1382 1L
EUR 134.4

4L Oxosol 306

NAT1384 4L
EUR 279.6

One patient who later developed invasive ductal carcinoma in the contralateral breast ATM may have a germ line mutation. Our results confirm the hotspot mutations in PIK3CA and AKT1 gene in JP associated with a positive family history of breast cancer, although the mutation is not specific to JP.