juvenile polyps are the most common types of polyps in children but rare in adults. inflammatory bowel disease (IBD) patients had the same spectrum of symptoms as patients with juvenile polyps. Both patients with polyps teenagers and people with active IBD have high fecal calprotectin levels. Four cases of children with ulcerative colitis (UC) with solitary juvenile polyps and one adult case with UC with juvenile polyposis syndrome have been reported in the diagnosis of UC, while there was no case of adults with UC with solitary juvenile polyps were reported in men literature.
A 37 years with a 12 year history of UC was brought to our clinic because of the increased frequency of bowel movements. UC was diagnosed at the age of 25. As the lesions confined to the rectum, sulfasalazine Mesalazine suppositories or suppositories are used. Patients were followed at an outpatient clinic, and a colonoscopy done every one or two years. The latest inspection conducted three years before in the presence of proctitis.
More recently, the patient complained of three to five bowel movements a day. There is mucus in the stool but no blood visible. Colonoscopy revealed a solitary polyp, about 1.5 cm, with a short and wide rods in the transverse colon mucosa surrounded by congestive and edema. The patient had no family history of colorectal polyps or cancer. polyp was successfully removed by endoscopic mucosal resection.
Histopathological examination revealed that the juvenile polyp is a polyp without signs of malignant. Immunohistochemical staining for p53 expression of wild type and p53 excess undetected. Ki-67 labeling index was 3% .This is the first case of adult UC patients with solitary juvenile polyps in the 12-year follow-up. The correlation between juvenile polyps and IBD activity requires further research.

juvenile papillomatosis of breast (Swiss cheese disease) have frequent association with PIK3CA and / or mutation of AKT1.
Juvenile papillomatosis (JP), the so-called Swiss cheese disease is a rare benign breast disease of young adults. Associations (up 28%) with breast cancer in the family affected patients have been reported. A cystic mass breast lesions and calcifications multinodular JP characterize the imaging study.
Breast cancer develops only at very low part of the patient. JP molecular background has not been studied until now. In this study, we discuss the case of JP mutation analysis and correlate these results with follow-up and family-history in the context of the comprehensive review of the literature JP. We identified 13 cases that meet the criteria of JP. All patients were women with an average age of 38 years (26 to 50 years). follow-up information is available in 11 of 13 patients. Quite paraffin embedded tissue and DNA quality was good for the next generation sequencing (NGS) is available in 10 patients.
In 5 of the 10 patients, we found PIK3CA mutations in 2 of 10 patients in the AKT1 mutation hotspot known. further mutation in the MET gene, FGFR3, PTEN, ATM, NF1 and gnas detected in individual patients. Some of these mutations are present at high allele frequencies showed mutations in the germ line. 2 of 3 patients with a positive family history had PIK3CA mutations; one patient with a positive family history had a mutation in AKT1.
Hydrogen Peroxide Assay Kit |
|||
NAT1002 | National Diagnostics | 1KIT | EUR 308.4 |
ProtoBlock System |
|||
NAT1004 | National Diagnostics | 1KIT | EUR 122.4 |
450ML PBS 10X |
|||
NAT1006 | National Diagnostics | 450ML | EUR 96 |
4L PBS 10X |
|||
NAT1008 | National Diagnostics | 4L | EUR 238.8 |
ProtoGlow ECL 200ml Kit |
|||
NAT1010 | National Diagnostics | EACH | EUR 354 |
ProtoGlow ECL 500ml Kit |
|||
NAT1012 | National Diagnostics | EACH | EUR 627.6 |
100G Acrylamide |
|||
NAT1014 | National Diagnostics | 100G | EUR 120 |
500G Acrylamide |
|||
NAT1016 | National Diagnostics | 500G | EUR 261.6 |
1KG Acrylamide |
|||
NAT1018 | National Diagnostics | 1KG | EUR 412.8 |
25G AquaPor LE |
|||
NAT1020 | National Diagnostics | 25G | EUR 132 |
100G AquaPor LE GTAC |
|||
NAT1022 | National Diagnostics | 100G | EUR 250.8 |
500G AquaPor LE GTAC |
|||
NAT1024 | National Diagnostics | 500G | EUR 878.4 |
25G AquaPor ES |
|||
NAT1026 | National Diagnostics | 25G | EUR 152.4 |
100G AquaPor ES |
|||
NAT1028 | National Diagnostics | 100G | EUR 350.4 |
25G AquaPor LM |
|||
NAT1030 | National Diagnostics | 25G | EUR 288 |
100G AquaPor LM |
|||
NAT1032 | National Diagnostics | 100G | EUR 860.4 |
25G AquaPor HR |
|||
NAT1034 | National Diagnostics | 25G | EUR 236.4 |
100G AquaPor HR |
|||
NAT1036 | National Diagnostics | 100G | EUR 592.8 |
25G AquaPor 3:1 |
|||
NAT1038 | National Diagnostics | 25G | EUR 250.8 |
100G AquaPor 3:1 |
|||
NAT1040 | National Diagnostics | 100G | EUR 570 |
25G Bis (Methylene Bis-Acrylamide) |
|||
NAT1042 | National Diagnostics | 25G | EUR 100.8 |
25G DATD Ultrapure |
|||
NAT1044 | National Diagnostics | 25G | EUR 168 |
250G Glycine |
|||
NAT1046 | National Diagnostics | 250G | EUR 94.8 |
1KG Glycine Ultrapure |
|||
NAT1048 | National Diagnostics | 1KG | EUR 128.4 |
250G Tris |
|||
NAT1050 | National Diagnostics | 250G | EUR 102 |
1KG Tris Ultrapure |
|||
NAT1052 | National Diagnostics | 1KG | EUR 177.6 |
100G Tricine |
|||
NAT1054 | National Diagnostics | 100G | EUR 120 |
100G Ion Exchange Resin (mixed bed) |
|||
NAT1056 | National Diagnostics | 100G | EUR 96 |
25G Riboflavin |
|||
NAT1058 | National Diagnostics | 25G | EUR 96 |
25ML TEMED |
|||
NAT1060 | National Diagnostics | 25ML | EUR 99.6 |
25G Ammonium Persulfate |
|||
NAT1062 | National Diagnostics | 25G | EUR 96 |
100G Ammonium Persulfate |
|||
NAT1064 | National Diagnostics | 100G | EUR 118.8 |
1G Dithiothreitol (DTT) |
|||
NAT1066 | National Diagnostics | 1G | EUR 103.2 |
5G Dithiothreitol (DTT) |
|||
NAT1068 | National Diagnostics | 5G | EUR 183.6 |
50ML 2-Mercaptoethanol |
|||
NAT1070 | National Diagnostics | 50ML | EUR 112.8 |
100G SDS Ultrapure |
|||
NAT1072 | National Diagnostics | 100G | EUR 111.6 |
1KG SDS Ultrapure |
|||
NAT1074 | National Diagnostics | 1KG | EUR 457.2 |
250G Urea |
|||
NAT1076 | National Diagnostics | 250G | EUR 98.4 |
1KG Urea |
|||
NAT1078 | National Diagnostics | 1KG | EUR 138 |
450ML Glycerol Ultrapure |
|||
NAT1080 | National Diagnostics | 450ML | EUR 132 |
200ML Tween 20 Ultrapure |
|||
NAT1082 | National Diagnostics | 200ML | EUR 132 |
1L Tween 20 |
|||
NAT1084 | National Diagnostics | 1L | EUR 169.2 |
200ML Formamide |
|||
NAT1086 | National Diagnostics | 200ML | EUR 111.6 |
500ML Boric Acid |
|||
NAT1088 | National Diagnostics | 500ML | EUR 103.2 |
100G EDTA |
|||
NAT1090 | National Diagnostics | 100G | EUR 94.8 |
500G EDTA |
|||
NAT1092 | National Diagnostics | 500G | EUR 177.6 |
GelDry Film 11 X 12 cm |
|||
NAT1094 | National Diagnostics | PK50 | EUR 100.8 |
25ML Formamide CE |
|||
NAT1096 | National Diagnostics | 25ML | Ask for price |
25ML Glass Bond |
|||
NAT1098 | National Diagnostics | 25ML | EUR 158.4 |
450ML Glass Free |
|||
NAT1100 | National Diagnostics | 450ML | EUR 196.8 |
GelDry Film 22.5 X 22.5 cm |
|||
NAT1102 | National Diagnostics | PK50 | EUR 130.8 |
1L DEPC Treated Water |
|||
NAT1104 | National Diagnostics | 1L | EUR 120 |
Sterling Rapid Silver Stain Kit |
|||
NAT1106 | National Diagnostics | 1KIT | EUR 265.2 |
1L ProtoBlue Safe |
|||
NAT1108 | National Diagnostics | 1L | EUR 159.6 |
4L ProtoBlue Safe |
|||
NAT1110 | National Diagnostics | 4L | EUR 282 |
1L ProtoStain Blue |
|||
NAT1112 | National Diagnostics | 1L | EUR 164.4 |
25ML Nuclistain |
|||
NAT1114 | National Diagnostics | 25ML | EUR 128.4 |
450ML AcrylaGel 30% |
|||
NAT1116 | National Diagnostics | 450ML | EUR 128.4 |
1L AcrylaGel 30% |
|||
NAT1118 | National Diagnostics | 1L | EUR 177.6 |
450ML Bis-AcrylaGel 2% |
|||
NAT1120 | National Diagnostics | 450ML | EUR 98.4 |
1L Bis-AcrylaGel 2% |
|||
NAT1122 | National Diagnostics | 1L | EUR 111.6 |
450ML UreaGel 29:1 Concentrate |
|||
NAT1124 | National Diagnostics | 450ML | EUR 133.2 |
1L UreaGel 29:1 Concentrate |
|||
NAT1126 | National Diagnostics | 1L | EUR 183.6 |
UreaGel 29:1 System 1L Kit |
|||
NAT1128 | National Diagnostics | EACH | EUR 171.6 |
UreaGel 29:1 System 2.2L Kit |
|||
NAT1130 | National Diagnostics | EACH | EUR 253.2 |
450ML SequaGel UreaGel Concentrate |
|||
NAT1132 | National Diagnostics | 450ML | EUR 126 |
1L SequaGel UreaGel Concentrate |
|||
NAT1134 | National Diagnostics | 1L | EUR 160.8 |
SequaGel Sequencing System 1L Kit |
|||
NAT1136 | National Diagnostics | 1KIT | EUR 171.6 |
SequaGel Sequencing System 2.2L Kit |
|||
NAT1138 | National Diagnostics | EACH | EUR 253.2 |
100ML SequaGel Buffer |
|||
NAT1140 | National Diagnostics | 100ML | EUR 80.4 |
200ML SequaGel UreaGel Buffer |
|||
NAT1142 | National Diagnostics | 200ML | EUR 84 |
450ML SequaGel UreaGel-6 |
|||
NAT1144 | National Diagnostics | 450ML | EUR 115.2 |
1L SequaGel UreaGel-6 |
|||
NAT1146 | National Diagnostics | 1L | EUR 151.2 |
450ML SequaGel UreaGel-8 |
|||
NAT1148 | National Diagnostics | 450ML | EUR 115.2 |
1L SequaGel UreaGel-8 |
|||
NAT1150 | National Diagnostics | 1L | EUR 151.2 |
450ML SequaGel UreaGel Diluent |
|||
NAT1152 | National Diagnostics | 450ML | EUR 90 |
1L SequaGel UreaGel Diluent |
|||
NAT1154 | National Diagnostics | 1L | EUR 103.2 |
90ML SequaGel Complete Buffer |
|||
NAT1156 | National Diagnostics | 90ML | EUR 79.2 |
200ML SequaGel UreaGel Complete Buffer |
|||
NAT1158 | National Diagnostics | 200ML | EUR 85.2 |
450ML SequaGel XR |
|||
NAT1160 | National Diagnostics | 450ML | EUR 126 |
1L SequaGel XR |
|||
NAT1162 | National Diagnostics | 1L | EUR 165.6 |
100ML SequaGel XR Concentrate |
|||
NAT1164 | National Diagnostics | 100ML | EUR 128.4 |
450ML SequaGel XR Concentrate |
|||
NAT1166 | National Diagnostics | 450ML | EUR 361.2 |
200ML SequaGel MD Monomer Solution |
|||
NAT1168 | National Diagnostics | 200ML | EUR 220.8 |
SequaGel MD SSCP Kit |
|||
NAT1170 | National Diagnostics | 1KIT | EUR 253.2 |
SequaGel MD Heteroduplex Kit |
|||
NAT1172 | National Diagnostics | EACH | EUR 265.2 |
1.2ML SequaGel MD SSCP Stop Solution |
|||
NAT1174 | National Diagnostics | 1.2ML | EUR 85.2 |
450ML AccuGel 19:1 (30%) |
|||
NAT1176 | National Diagnostics | 450ML | EUR 126 |
1L AccuGel 19:1 (30%) |
|||
NAT1178 | National Diagnostics | 1L | EUR 165.6 |
450ML AccuGel 19:1 (40%) |
|||
NAT1180 | National Diagnostics | 450ML | EUR 130.8 |
1L AccuGel 19:1 (40%) |
|||
NAT1182 | National Diagnostics | 1L | EUR 168 |
450ML AccuGel 29:1 (30%) |
|||
NAT1184 | National Diagnostics | 450ML | EUR 126 |
1L AccuGel 29:1 (30%) |
|||
NAT1186 | National Diagnostics | 1L | EUR 165.6 |
450ML AccuGel 29:1 (40%) |
|||
NAT1188 | National Diagnostics | 450ML | EUR 130.8 |
1L AccuGel 29:1 (40%) |
|||
NAT1190 | National Diagnostics | 1L | EUR 168 |
1.2ML Triple Dye Loading Buffer (6X) |
|||
NAT1192 | National Diagnostics | 1.2ML | EUR 85.2 |
UreaGel Loading Buffer |
|||
NAT1194 | National Diagnostics | 10X1ML | EUR 222 |
1L TBE 10X |
|||
NAT1196 | National Diagnostics | 1L | EUR 98.4 |
4L TBE 10X |
|||
NAT1198 | National Diagnostics | 4L | EUR 145.2 |
1L TBE 5X |
|||
NAT1200 | National Diagnostics | 1L | EUR 92.4 |
4L TBE 5X |
|||
NAT1202 | National Diagnostics | 4L | EUR 111.6 |
25ML TE BUFFER 100X |
|||
NAT1204 | National Diagnostics | 25ML | EUR 98.4 |
25ML 10X CE Buffer |
|||
NAT1206 | National Diagnostics | 25ML | EUR 138 |
100ML 10X CE Buffer |
|||
NAT1208 | National Diagnostics | 100ML | EUR 196.8 |
450ML 20X Tris-MOPS SDS |
|||
NAT1210 | National Diagnostics | 450ML | EUR 130.8 |
450ML 20X Tris-MEPS SDS |
|||
NAT1212 | National Diagnostics | 450ML | EUR 130.8 |
1L Tris-Tricine-SDS PAGE Buffer (10X) |
|||
NAT1214 | National Diagnostics | 1L | EUR 217.2 |
1L Tris-Glycine-SDS PAGE Buffer (10X) |
|||
NAT1216 | National Diagnostics | 1L | EUR 105.6 |
4L Tris-Glycine-SDS PAGE Buffer (10X) |
|||
NAT1218 | National Diagnostics | 4L | EUR 148.8 |
1L TTE Glycerol Tolerant Buffer 20X |
|||
NAT1220 | National Diagnostics | 1L | EUR 160.8 |
1L TAE Buffer 50X |
|||
NAT1222 | National Diagnostics | 1L | EUR 148.8 |
1L SSC Buffer 20X |
|||
NAT1224 | National Diagnostics | 1L | EUR 98.4 |
4L SSC Buffer 20X |
|||
NAT1226 | National Diagnostics | 4L | EUR 174 |
100ML SDS Solution 20% |
|||
NAT1228 | National Diagnostics | 100ML | EUR 92.4 |
450ML SDS Solution 20% |
|||
NAT1230 | National Diagnostics | 450ML | EUR 138 |
1L Denaturation Solution |
|||
NAT1232 | National Diagnostics | 1L | EUR 102 |
1L Neutralization Solution |
|||
NAT1234 | National Diagnostics | 1L | EUR 102 |
50G Dextran Sulfate |
|||
NAT1236 | National Diagnostics | 50G | EUR 193.2 |
250G Dextran Sulfate |
|||
NAT1238 | National Diagnostics | 250G | EUR 524.4 |
1L Tris-Glycine Electroblotting Buffer 10X |
|||
NAT1240 | National Diagnostics | 1L | EUR 102 |
4L Tris-Glycine Electroblotting Buffer 10X |
|||
NAT1242 | National Diagnostics | 4L | EUR 145.2 |
1L TBS (10X) Tris Buffered Saline |
|||
NAT1244 | National Diagnostics | 1L | EUR 126 |
1L TBST (10X) Tris Buffered Saline w/Tween 20 |
|||
NAT1246 | National Diagnostics | 1L | EUR 126 |
ProtoGel Sample Prep Kit |
|||
NAT1248 | National Diagnostics | EACH | EUR 223.2 |
Protein Loading Buffer Blue 2X |
|||
NAT1250 | National Diagnostics | 10X1ML | EUR 105.6 |
Protein Loading Buffer 5X |
|||
NAT1252 | National Diagnostics | 10X1ML | EUR 151.2 |
50ML Protein Precipitation Kit |
|||
NAT1254 | National Diagnostics | 50ML | EUR 270 |
100ML ProtoLift Western Strip Buffer |
|||
NAT1256 | National Diagnostics | 100ML | EUR 121.2 |
450ML ProtoGel (30%) |
|||
NAT1258 | National Diagnostics | 450ML | EUR 136.8 |
1L ProtoGel (30%) |
|||
NAT1260 | National Diagnostics | 1L | EUR 187.2 |
450ML ProtoGel (40%) |
|||
NAT1262 | National Diagnostics | 450ML | EUR 157.2 |
1L ProtoGel (40%) |
|||
NAT1264 | National Diagnostics | 1L | EUR 204 |
450ML ProtoGel Resolving Buffer 4X |
|||
NAT1266 | National Diagnostics | 450ML | EUR 100.8 |
1L ProtoGel Resolving Buffer |
|||
NAT1268 | National Diagnostics | 1L | EUR 128.4 |
200ML ProtoGel Stacking Buffer |
|||
NAT1270 | National Diagnostics | 200ML | EUR 92.4 |
100ML ProtoGel Quick-Cast 12% |
|||
NAT1272 | National Diagnostics | 100ML | EUR 105.6 |
450ML ProtoGel Quick-Cast 12% |
|||
NAT1274 | National Diagnostics | 450ML | EUR 223.2 |
0.5ML Insite Markers |
|||
NAT1276 | National Diagnostics | 0.5ML | EUR 238.8 |
0.5ML ProtoMarkers |
|||
NAT1278 | National Diagnostics | 0.5ML | EUR 236.4 |
ProtoMetrics |
|||
NAT1280 | National Diagnostics | EACH | EUR 242.4 |
1L EDTA 0.5M Solution |
|||
NAT1282 | National Diagnostics | 1L | EUR 183.6 |
1L Sodium Chloride 0.009 Solution |
|||
NAT1284 | National Diagnostics | 1L | EUR 140.4 |
1L Sodium Chloride 1M Solution |
|||
NAT1286 | National Diagnostics | 1L | EUR 140.4 |
1L Potassium Chloride 1M Solution |
|||
NAT1288 | National Diagnostics | 1L | EUR 140.4 |
1L Tris-HCL 1M pH 7.2 |
|||
NAT1290 | National Diagnostics | 1L | EUR 126 |
1L Tris-HCL 1M pH 7.4 |
|||
NAT1292 | National Diagnostics | 1L | EUR 126 |
1L Tris-HCL 1M pH 7.6 |
|||
NAT1294 | National Diagnostics | 1L | EUR 126 |
Histosol |
|||
NAT1296 | National Diagnostics | EACH | EUR 106.8 |
Histosol |
|||
NAT1298 | National Diagnostics | EACH | EUR 270 |
Mirskys Fixative (ready-to-use) |
|||
NAT1300 | National Diagnostics | 1USGALLON | EUR 96 |
Mirskys Fixative (ready-to-use) |
|||
NAT1302 | National Diagnostics | EACH | EUR 228 |
200ML Mirskys Fixative |
|||
NAT1304 | National Diagnostics | 200ML | EUR 92.4 |
2L Mirskys Fixative |
|||
NAT1306 | National Diagnostics | 2L | EUR 134.4 |
100ML Histomount |
|||
NAT1308 | National Diagnostics | 100ML | EUR 86.4 |
450ML Histomount |
|||
NAT1310 | National Diagnostics | 450ML | EUR 111.6 |
Calci-Clear |
|||
NAT1312 | National Diagnostics | EACH | EUR 93.6 |
Calci-Clear |
|||
NAT1314 | National Diagnostics | EACH | EUR 153.6 |
Calci-Clear |
|||
NAT1316 | National Diagnostics | EACH | EUR 463.2 |
Calci-Clear Rapid |
|||
NAT1318 | National Diagnostics | EACH | EUR 90 |
Calci-Clear Rapid |
|||
NAT1320 | National Diagnostics | EACH | EUR 153.6 |
Calci-Clear Rapid |
|||
NAT1322 | National Diagnostics | EACH | EUR 463.2 |
100ML Hydromount |
|||
NAT1324 | National Diagnostics | 100ML | EUR 110.4 |
Neutralin |
|||
NAT1326 | National Diagnostics | 5USGALLON | EUR 136.8 |
100ML Omnimount |
|||
NAT1328 | National Diagnostics | 100ML | EUR 93.6 |
Histo-Clear |
|||
NAT1330 | National Diagnostics | 1 US gallon | EUR 184 |
Histo-Clear |
|||
NAT1332 | National Diagnostics | 5 US gallons | EUR 699.6 |
Histo-Clear II |
|||
NAT1334 | National Diagnostics | 1 US gallon | EUR 151.2 |
Histo-Clear II |
|||
NAT1336 | National Diagnostics | 5 US gallons | EUR 457.2 |
1L HarrisHematoxylin |
|||
NAT1338 | National Diagnostics | 1L | EUR 147.6 |
100ML Eosin Solution |
|||
NAT1340 | National Diagnostics | 100ML | EUR 106.8 |
1L Scotts Tapwater |
|||
NAT1342 | National Diagnostics | 1L | EUR 90 |
25G Alcian Blue |
|||
NAT1344 | National Diagnostics | 25G | EUR 194.4 |
25G Biebrich Scarlet |
|||
NAT1346 | National Diagnostics | 25G | EUR 144 |
25G Fast Green FCF |
|||
NAT1348 | National Diagnostics | 25G | EUR 192 |
25G Basic Fuchsin |
|||
NAT1350 | National Diagnostics | 25G | EUR 352.8 |
25G Methylene Blue |
|||
NAT1352 | National Diagnostics | 25G | EUR 187.2 |
25G Amido Black 10B |
|||
NAT1354 | National Diagnostics | 25G | EUR 176.4 |
5G Bromocresol Green |
|||
NAT1356 | National Diagnostics | 5G | EUR 187.2 |
10G Bromophenol Blue |
|||
NAT1358 | National Diagnostics | 10G | EUR 169.2 |
10G Coomassie Blue R-250 |
|||
NAT1360 | National Diagnostics | 10G | EUR 123.6 |
10G Coomassie Blue G-250 |
|||
NAT1362 | National Diagnostics | 10G | EUR 177.6 |
10G Methyl Green |
|||
NAT1364 | National Diagnostics | 10G | EUR 211.2 |
5G Pyronin Y |
|||
NAT1366 | National Diagnostics | 5G | EUR 261.6 |
25G Xylene Cyanol FF |
|||
NAT1368 | National Diagnostics | 25G | EUR 231.6 |
4L Hydrofluor |
|||
NAT1370 | National Diagnostics | 4L | EUR 200.4 |
4L Liquiscint |
|||
NAT1372 | National Diagnostics | 4L | EUR 168 |
4L Betafluor |
|||
NAT1374 | National Diagnostics | 4L | EUR 158.4 |
4L Monofluor |
|||
NAT1376 | National Diagnostics | 4L | EUR 234 |
4L Filtron-X |
|||
NAT1378 | National Diagnostics | 4L | EUR 252 |
Oxosol C14 Oxidizer |
|||
NAT1380 | National Diagnostics | EACH | EUR 322.8 |
1L Oxosol 306 |
|||
NAT1382 | National Diagnostics | 1L | EUR 134.4 |
4L Oxosol 306 |
|||
NAT1384 | National Diagnostics | 4L | EUR 279.6 |
One patient who later developed invasive ductal carcinoma in the contralateral breast ATM may have a germ line mutation. Our results confirm the hotspot mutations in PIK3CA and AKT1 gene in JP associated with a positive family history of breast cancer, although the mutation is not specific to JP.