Pediatricians’ Perceptions Toward Do Not Resuscitate: A Survey in Saudi Arabia and Literature Review.
by Kaitlin
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To explore attitudes and perceptions towards pediatricians do-not-Resuscitate (DNR) order on certain regions of the world are not fully explored before.A cross-sectional study was conducted between March 4 and May 30, 2018. The pediatrician from three public hospitals in the city Riyadh were asked to respond to the questionnaire consisting of 22 questions designed to meet the objectives of our research.
result A total of 203 pediatricians (51.2% female) completed the questionnaire, both pediatricians junior (JPs) and senior pediatrician (SPs). The majority (58.9% of JPs and 61.4% of SPs) think the patient has the right to require intensive care, although their terminal illness. Half the participants in both groups think that the DNR is the doctor’s decision. Only 9.3% of JPs and 12.5% of SPs feel comfortable discussing DNR with patients / families.
medical schools are also a source of knowledge about the issues DNR, especially for JPs (40.2% vs 20.8% of JPs of SPs, P = 0.005). Half the participants felt that the DNR is consistent with Islamic beliefs, while 57.9% of JPs vs 41.7% of SPs feel they are protected by law. hospital’s policy is clearly to 48.6% from 66.7% vs JPs of SPs, while clear procedures to 35.5% of JPs vs. 49% of SPs.
Several factors are present that can hinder the implementation of the DNR, as doubts about the legally protected, doubts about the consistency with Islamic sharia, unclear policies and procedures, and a lack of training and orientation on issues DNR. Policies may need to include patients as decision makers.
Pediatricians’ Perceptions Toward Do Not Resuscitate: A Survey in Saudi Arabia and Literature Review.
The characteristics of nonsyndromic and potentially polyps Juvenile polyps syndrome: A retrospective cohort analysis.
Juvenile polyps (JPs) are the most common gastrointestinal polyps were diagnosed in children. There is a lack of evidence to distinguish groups of polyps and presence burden and importance of neoplastic changes.A retrospective chart review of patients, ages birth to 18 years old with nonsyndromic JPs conducted from 2003 to 2017.
Data abstracted included basic demographics, age, clinical presentation, colonoscopy findings, and reports pathology. Slide polyps with neoplasia reviewed by pathologist.A total of 213 subjects underwent 326 procedures and 435 polypectomies. Subjects with a positive family history, positive gene mutation, or many (> 10) polyps removed. The group is defined by the number of polyps (1, 2-4, 5-10).
Repeat colonoscopy polyp recurrence was significantly associated with polyp burden (1 polyps: 1.5% / 19.2% of polyps 2-4 / 5-10 polyps 82.6%: P <0.001). distribution of polyps was significantly different between the different groups to support the distribution of isolated distal polyps. JPs keep focus adenomatous reported in 26 (12%) patients. JPs keep focus adenomatous were significantly more likely to be distributed proximal but the existence of a transformation in the adenomatous polyps do not correlate with the number of polyps or possible recurrence of polyps in the repeat colonoscopy.
JP recurrence positive and significant effect associated with polyp burden. JP harbored adenomatous changes independent of the number of polyps, underlining the possible malignant potential in JPs. In the absence of a consistent genotype or pedigree, the presence of adenomatous transformation in JPs should not be construed as a biomarker for teenagers polyposis.JLP syndrome MPS families whose members belong to function as a scaffold protein that links the motor proteins and their cargo for intracellular transport.
Description: A polyclonal antibody for detection of JIP-1 from Human, Mouse, Rat. This JIP-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human JIP-1 around the non-phosphorylation site of T103
Description: A polyclonal antibody for detection of JIP-1 from Human, Mouse, Rat. This JIP-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human JIP-1 around the non-phosphorylation site of T103
Description: A polyclonal antibody for detection of JIP-1 from Human, Mouse, Rat. This JIP-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human JIP-1 around the non-phosphorylation site of T103
Description: MAPK8IP1 encodes a regulator of the pancreatic beta-cell function. C-Jun-amino-terminal kinase-interacting protein 1 is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). C-Jun-amino-terminal kinase-interacting protein 1 has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
Description: MAPK8IP1 encodes a regulator of the pancreatic beta-cell function. C-Jun-amino-terminal kinase-interacting protein 1 is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). C-Jun-amino-terminal kinase-interacting protein 1 has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
Description: MAPK8IP1 encodes a regulator of the pancreatic beta-cell function. C-Jun-amino-terminal kinase-interacting protein 1 is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). C-Jun-amino-terminal kinase-interacting protein 1 has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
Description: A polyclonal antibody for detection of JIP-1 phospho Thr103) from Human, Mouse, Rat. This JIP-1 phospho Thr103) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human JIP-1 around the phosphorylation site of T103
Description: A polyclonal antibody for detection of JIP-1 phospho Thr103) from Human, Mouse, Rat. This JIP-1 phospho Thr103) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human JIP-1 around the phosphorylation site of T103
Description: A polyclonal antibody for detection of JIP-1 phospho Thr103) from Human, Mouse, Rat. This JIP-1 phospho Thr103) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human JIP-1 around the phosphorylation site of T103
Description: This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
Description: This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
Description: This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
Description: A polyclonal antibody for detection of JIP-3 from Human, Mouse. This JIP-3 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human JIP-3 at AA range: 590-670
Description: A polyclonal antibody for detection of JIP-3 from Human, Mouse. This JIP-3 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human JIP-3 at AA range: 590-670
Description: A polyclonal antibody for detection of JIP-3 from Human, Mouse. This JIP-3 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human JIP-3 at AA range: 590-670
Description: A polyclonal antibody for detection of JIP-2 from Human, Mouse, Rat. This JIP-2 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human JIP-2 at AA rangle: 550-630
Description: A polyclonal antibody for detection of JIP-2 from Human, Mouse, Rat. This JIP-2 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human JIP-2 at AA rangle: 550-630
Description: A polyclonal antibody for detection of JIP-2 from Human, Mouse, Rat. This JIP-2 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human JIP-2 at AA rangle: 550-630
Description: The mitogen-activated protein kinase 8 interacting protein 2 encoded by MAPK8IP2 is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells.
Description: The mitogen-activated protein kinase 8 interacting protein 2 encoded by MAPK8IP2 is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells.
Description: The mitogen-activated protein kinase 8 interacting protein 2 encoded by MAPK8IP2 is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells.
Description: C-Jun-amino-terminal kinase-interacting protein 3 encoded by MAPK8IP3 shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Description: C-Jun-amino-terminal kinase-interacting protein 3 encoded by MAPK8IP3 shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Description: C-Jun-amino-terminal kinase-interacting protein 3 encoded by MAPK8IP3 shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Description: A Rabbit Polyclonal antibody against JIP-1 (phospho Thr103) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A Rabbit Polyclonal antibody against JIP-1 (phospho Thr103) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: Boster Bio Anti-Phospho-JIP-1 (T103) MAPK8IP1 Antibody catalog # A05068T103. Tested in ELISA, IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Although JLP especially cytoplasm, it accumulates as a focus in the perinuclear region when stimulated by extracellular stimuli. focus formation, which change the shape of the nucleus and nuclear pores concentrate, depending on the activation of p38MAPK and retrograde dynein motor protein complex. Extracellular stimuli lead to the withdrawal of PLK1 to centrosome by the JLP, which leads to the maturation of the centrosome and microtubule formation arrays.
